Clinical and molecular categorization of progressive, adult-onset cutaneous mastocytosis
نویسندگان
چکیده
BMAT: bone marrow aspirate and trephine CM: cutaneous mastocytosis CT: computed tomography UP: urticaria pigmentosa SM: systemic mastocytosis TMEP: telangiectasia macularis eruptive perstans WHO: World Health Organization INTRODUCTION Diagnosis of mastocytosis is frequently delayed given the variable clinical phenotypes at presentation. Here we present a case of a 64-year-old woman diagnosed with cutaneous mastocytosis (CM), specifically urticaria pigmentosa (UP), initially localized to an area treated with radiotherapy that subsequently progressed to indolent systemic mastocytosis (SM).
منابع مشابه
Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment
BACKGROUND Mastocytosis is either cutaneous (with skin-limited proliferation of mast cells) or systemic (with mast cells in extracutaneous sites). The onset of solitary mastocytoma in an adult is rare. PURPOSE A woman with the new onset of solitary mastocytoma is described. The clinical features of patients with adult-onset solitary mastocytoma are summarized. Recommendations for the evaluati...
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Mastocytosis most frequently manifests in the skin, so most often is diagnosed by dermatologists at first. Low threshold in clinical suspicion helps early detection of these cases. Cutaneous mastocytosis is an increase of cutaneous mast cells without known underlying disease or inflammatory infiltrate. A skin biopsy with staining specific for mast cells (toluidine blue, Wright-Giemsa) and trypt...
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diagnosis or during follow-up. Our twins were unusual because of the onset of cutaneous lesions during adult life. One had systemic symptoms presumed to be related to the release of mast cellederived mediators (histamine, prostaglandins), but neither had evidence of extracutaneous disease. Age at onset influences the clinical behavior of mastocytosis. Pediatric mastocytosis often resolves spont...
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